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British Journal of Anaesthesia, 1980, Vol. 52, No. suppl_1 21S-32S
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Comparison of the Cardiovascular Actions of Org NC 45 with Those Produced By Other Non-Depolarizing Neuromuscular Blocking Agents in Experimental Animals

R. J. Marshall, B.SC., PH.D.*, J. C. McGrath, B.SC., PH.D., R. D. Miller, M.D., J. R. Docherty, B.SC., PH.D. and J. -C. Lamar

Department of Physiology and Pharmacology, University of Strathclyde Glasgow
Department of Physiology, University of Glasgow Glasgow
Department of Anesthesia and Pharmacology, University of California San Francisco, U.S.A.
Scientific Development Group, Organon International B.V. Oss, Holland

The cardiovascular actions of 1- [(2β, 3{alpha}, 16β,17β)]-3,17-bis(acetyloxy)-2-(I-piperidiny)-androstan-16-yl]-1-methyl-piperidiniuim bromide (Org NC 45) are reviewed and compared with those of other nondepolarizing neuromuscular blocking drugs. Results obtained in ansesthetized cats and dogs have demonstrated that, in contrast to other neuromuscular blocking drugs, Org NC 45, even in doses 20 times greater than those required for neuromuscular block, has no effects on heart rate, arterial pressure, autonomic ganglia, adrenoceptors or baroreceptor activity. Studies in pithed rats and on guineapig atria have further shown that Org NC 45 has little effect on cardiac muscarinic receptors or on noradrenaline re-uptake mechanisms. These results suggest that Org NC 45 possesses significant advantages over presently used non-depolarizing neuromuscular blocking drugs since its clinical use should not be associated with cardiovascular side-effects.

* Present address, for reprints: Scientific Development Group, Organon Laboratories Limited, Newhouse, Lan arkshire ML1 5SH.


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