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British Journal of Anaesthesia, 1980, Vol. 52, No. 2 199-204
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECTS OF ANAESTHETICS ON GUINEAPIG TRACHEAL SMOOTH MUSCLE

F. OKUMURA, M.D., PH.D. and M. A. DENBOROUGH, M.D., D.PHIL., D.SC., F.R.C.P., F.R.A.C.P.

Department of Clinical Science, John Curtin School of Medical Research, The Australian National University Canberra, A.C.T. 2601, Australia

The effects of i.v. and local anaesthetics on guineapig tracheal smooth muscle have been investigated in vitro. Diazepam, propanidid and ketamine induced relaxation and antagonized histamine-, acetylcholine- and potassium chloride-induced contractures in the tracheal smooth muscle. The relaxing effects of the anaesthetics were not affected by propranoioi. Thiopentone, at concentrations which would be used clinically, caused contracture of the tracheal smooth muscle. Morphine induced relaxation and antagonized histamine-induced contracture, but did not antagonize acetyicholine- or potassium chloride-induced contractures. Lignocaine and procaine, at clinical concentrations, induced contracture of tracheal smooth muscle. Large doses of lignocaine relaxed the tracheal muscle, but large doses of procaine induced spontaneous rhythmical movements. Lignocaine and procaine antagonized contractures induced by histamine, acetylcholine and potassium chloride.

Present address: Department of Anesthesiology, National Cardiovascular Center, Fujishirodai Suita, Osaka, Japan 565.


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