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British Journal of Anaesthesia, 1980, Vol. 52, No. 1 91-96
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

I.V. PRACTOLOL DURING MICROLARYNGOSCOPY. EFFECT ON ARTERIAL PRESSURE, HEART RATE, BLOOD GLUCOSE AND LIPOLYSIS

O. WERNER, M.D., J. MAGNUSSON, M.D., R. FLETCHER, F.F.A.R.C.S., P. NILSSON-EHLE, M.D. and O. PAHLM, M.D.

Department of Anaesthesia S-221 85 Lund, Sweden
Department of Clinical Chemistry S-221 85 Lund, Sweden
Department of Clinical Physiology. University Hospital of Lund S-221 85 Lund, Sweden

Twenty-five patients undergoing microlaryngoscopy were anaesthetized with thiopentone and nitrous oxide with suxamethonium as a muscle relaxant. Thirteen received practolol 0.4 mg kg–1 and atropine 1.5mg i.v. shortly before anaesthesia. During anaesthesia practolol 0.2 mg kg–1 was given. Twelve (control) received atropine 0.5 mg before anaesthesia. Practolol reduced the frequency of tachycardia and arrhythmia. The treatment group had a greater reduction in systolic arterial pressure during induction. The hypertensive response to laryngoscopy was not significantly attenuated by practolol. A weak hyperglycaemic response to microlaryngoscopy was not affected, nor was the plasma concentration of glycerol.


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