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British Journal of Anaesthesia, 1980, Vol. 52, No. 1 85-89
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EVALUATION OF GLYCOPYRROLATE AND ATROPINE AS ADJUNCTS TO REVERSAL OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS IN A "TRUE-TO-LIFE" SITUATION

D. A. COZANITIS, B.SC.PHARM., D.T.M.H.*, J. W. DUNDEE, M.D., PH.D., F.F.A.R.C.S., M.R.C.P., J. D. MERRETT, PH.D., C. J. JONES, B.PHARM., M.P.S. and R. K. MIRAKHUR, M.D., PH.D., F.F.A.R.C.S.

Department of Anaesthetics, The Queen's University of Belfast Belfast, Northern Ireland
Department of Medical Statistics, The Queen's University of Belfast Redkiln Way, Horsham, W. Sussex
A. H. Robins Co. Redkiln Way, Horsham, W. Sussex

Glycopyrrolate, a quaternary ammonium anticholinergic compound, and atropine were evaluated in combination with neostigmine for antagonism of non-depolarizing neuromuscular block. A total of 641 patients were investigated in a "true-to-life" situation. The patients receiving glycopyrrolate with neostigmine had smaller changes in heart rate than those who received atropine. This was particularly apparent in patients with cardiovascular disease.

* Present address: Department of Anaesthesia, University Central Hospital, 00290 Helsinki, 29, Finland.


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