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British Journal of Anaesthesia, 1980, Vol. 52, No. 1 81-84
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECTS OF DOXAPRAM ON POSTOPERATIVE PULMONARY COMPLICATIONS FOLLOWING THORACOTOMY

P. S. SEBEL, M.B., B.S., F.F.A.R.C.S.I.*, E. J. KERSHAW, M.B., B.S., F.F.A.R.C.S. and W. S. RAO, M.D., F.F.A.R.C.S., D.A.

Brook Hospital London, SE 18

An i.v. solution of 5% dextrose with doxapram 2 mg ml–1 or 5% dextrose alone was administered to 53 patients following lateral thoracotomy. Estimations of arterial Po2 Pco2 and pH were made before operation, during infusion and 7 days after operation. Respiratory function tests were carried out before and 7 days after operation. There were no significant differences in arterial Po2 Pco2 and pH or in respiratory function tests between those who received doxapram and those who did not. In this study doxapram did not affect the frequency of postoperative pulmonary complications.

* Present address: Department of Anaesthetics, Wilhelmina Gasthuis, Academisch Ziekenhuis bij de Universiteit van Amsterdam, le Helmersstraat 104, Amsterdam, Holland.


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