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British Journal of Anaesthesia, 1980, Vol. 52, No. 1 77-79
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPLEMENT-MEDIATED REACTIONS TO DIAZEPAM WITH CREMOPHOR AS SOLVENT (STESOLID MR)

M. S. HÜTTEL, M.D., A. SCHOU OLESEN, M.D. and E. STOFFERSEN, MED.TECH.

Department of Anaesthetics and Intensive Therapy, and Section of Blood Coagulation, Department of Clinical Chemistry, Aalborg Hospital DK-9100 Aalborg, Denmark

Correspondence to M. H.: Sdr. Boulevard 164, 31, DK-5000 Odense C, Denmark

Changes in complement reactions are described in two patients exhibiting adverse reactions to Stesolid MR (diazepam with Cremophor as solvent). The recorded frequency of adverse reactions to Althesin, propanidid and Stesolid MR suggests that the common solvent Cremophor is responsible for the adverse reactions.


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