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British Journal of Anaesthesia, 1980, Vol. 52, No. 1 11-17
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PORCINE MALIGNANT HYPERTHERMIA. VII: HEPATIC METABOLISM

G. M. HALL, M.B., B.S., PH.D., M.I.BIOL., F.F.A.R.C.S., J. N. LUCKE, B.V.SC., M.R.C.V.S., PH.D., D.V.A., R. LOVELL, B.SC. and D. LISTER, B.SC., PH.D., F.I.BIOL.

Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital London W12 0HS
Department of Veterinary Surgery, University of Bristol Langford House, Langford, Bristol BS18 7DU
ARC Meat Research Institute Langford, Bristol BS18 7DY

Correspondence to G. M. H.

Hepatic metabolism during porcine malignant hyperthermia (MH) was investigated in seven Pietrain pigs. The estimated hepatic blood flow decreased during MH, but an increase in oxygen extraction enabled the splanchnic oxygen uptake to be maintained. There was a large release of glucose and potassium from the liver in MH which made an important contribution to the hyperglycaemia and hyperkalaemia. Measurement of hepatic uptake of the precursors of gluconeogenesis, lactate, glycerol and alanine, showed that glucose efflux from liver was derived mainly from glycogenolysis. Lactate uptake by the liver increased during MH, and there was no evidence of hepatic lactate production during the profound acidosis as suggested by in vitro studies with the isolated liver. There was no evidence of major abnormality of hepatic function during porcine MH.


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