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British Journal of Anaesthesia, 1979, Vol. 51, No. 5 417-421
© 1979 The Board of Management and Trustees of the British Journal of Anaesthesia

other

MUTAGENICITY OF INHALATION ANAESTHETICS: TRICHLOROETHYLENE, DIVINYL ETHER, NITROUS OXIDE AND CYCLOPROPANE*

J. M. BADEN, M.B., B.S., F.F.A.R.C.S., M.R.C.P., (U.K.), M. KELLEY, PH.D., R. I. MAZZE, M.D. and V. F. SIMMON, PH.D.

Anesthesiology Service (112A), VA Hospital, 3801 Miranda Avenue, Palo Alto California 94304, U.S.A.
Microbial Genetics Program, Stanford Research Institute International, Menlo Park California, U.S.A.

Correspondence to J. M. B.

The mutagenic potential of trichloroethylene, divinyl ether, nitrous oxide and cyclopropane was assessed in vitro by microbial assay employing two histidine-dependent strains of Salmonella typhimurium, TA1535 and TA100. Anaesthetic agents in various concentrations were incubated with bacteria in the presence or absence of an enzyme system prepared from enzyme-induced rat liver. Nitrous oxide and cyclopropane were not mutagenic, whereas divinyl ether gave a strongly positive response. Results for trichloroethylene were equivocal. These and previous studies with the salmonella system, together with mutagenicity studies using different test systems, indicate that modern inhalation anaesthetic agents are unlikely to be mutagenic.

* Presented at the 1978 Annual Meeting of the American Society of Anesthesiologists, Chicago, Illiniois.


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