British Journal of Anaesthesia, 1978, Vol. 50, No. 9 945-949
© 1978 The Board of Management and Trustees of the British Journal of Anaesthesia
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PLASMAPHERESIS AND PLASMA CHOLINESTERASE
Department of Anaesthetics, Hammersmith Hospital, Royal Pistgraduate Medical School London W12 OHS
Plasma cholinesterase (E.C. 3.1.1.8 [EC] ) concentrations were measured in nine outpatients who were undergoing regular plasmapheresis. A single plasmapheresis produced a 64% reduction in cholinesterase concentration compared with the value before plasmapheresis. Another patient who received four plasma exchanges in 6 days showed a progressive reduction in cholinesterase concentration to only 8% of the initial value. It is suggested that drugs metabolized by cholinesterase should be used with caution in patients undergoing plasmapheresis, particularly when frequent palsma exchanges are undertaken.
*Present address: Department of Anaesthetics, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ.
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