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British Journal of Anaesthesia, 1978, Vol. 50, No. 9 899-904
© 1978 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECTS OF HALOTHANE ON GLUCOSE METABOLISM AFTER INJURY IN THE RAT

D. F. HEATH, M.A., D.PHIL.*, K. N. FRAYN, PH.D., B.A.* and J. G. ROSE, M.I.BIOL.; M.R.C.*

Trauma Unit, Medical Research Council Laboratories Woodmansterne Road, Carshalton, Surrey SM5 4EF.

Correspondence to D. F. H.

The effects of halothane anaesthesia on glucose metabolism have been investigated in rats after a non-lethal scald injury. Anaesthesia was induced about 70 min after injury. Glucose metabolism was studied at two stages: during and shortly after induction, and about 2 h after induction. Comparisons were made with conscious rats at the corresponding times after injury. All rats were in an ambient temperature of 30 °C. During and shortly after the induction of anaesthesia, halothane caused a rapid increase in plasma glucose concentration, which by 30 min had begun to return to the values in injured controls; thus glucose production and utilization were increased. Insulin concentrations were increased also. However, after 2 h exposure halothane had decreased glucose production and utilization, as determined with [5-3H]-and [U-14C]-glucose, increased plasma concentrations of insulin and decreased liver concentrations of glycogen, that is it had exacerbated well-known effects of injury in the rat, including insulin resistance. Hyperglycaemia was not increased.

* Present address: M.R.C. Trauma Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PL.


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