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British Journal of Anaesthesia, 1978, Vol. 50, No. 9 885-889
© 1978 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECTS OF AGE AND SEX ON KETAMINE ANAESTHESIA IN THE RAT

A. E. WATERMAN, B.V.SC., D.V.A., PH.D., M.R.C.V.S. and A. LIVINGSTON, B.SC., B.VET.MED., PH.D., M.R.C.V.S.

Department of Pharmacology, Medical School, University of Bristol, University Walk Bristol BS8 1TD

Intraperitoneal injections of ketamine 75 mg kg-1 in rats of both sexes (age 1–16 weeks) revealed a significant relationship between increased age and decreased duration of sleeping time for both sexes during the first 3 weeks of age. This decrease in sleeping time seemed to be associated with the increased production of the cyclohexanone oxidation metabolite of ketamine. After 3 weeks of age there was a greater sleeping time in the female rat than the male and this seemed to be associated with a greater ability of the mke to produce the cyclohexanone oxidation metabolite.


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