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British Journal of Anaesthesia, 1977, Vol. 49, No. 9 927-933
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia

other

SOME CIRCULATORY AND RESPIRATORY EFFECTS OF MORPHINE IN PATIENTS WITHOUT PRE-EXISTING CARDIAC DISEASE

I. O. SAMUEL, M.S., D.A., R. S. J. CLARKE, M.D., PH.D., F.F.A.R.C.S. and J. W. DUNDEE, M.D., PH.D., F.F.A.R.C.S., M.R.C.P.

Department of Anaesthetics, The Queen's University of Belfast Northern Ireland

Haemodynamic and respiratory effects of i.v. morphine (10 mg/70 kg body weight) were studied in 10 adults with unimpaired circulatory function. There were significant changes in mean arterial pressure, mean heart rate, respiratory rate and tidal volume, at 10-, 30- and 60-min intervals. Transient changes in mean total systemic resistance and mean stroke volume were also seen at 10 min. The results strongly suggest a peripheral vasodilator response to morphine. Respiratory depression was not demonstrated.


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