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British Journal of Anaesthesia, 1977, Vol. 49, No. 9 901-905
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia

other

HAEMODYNAMIC RESPONSES TO ANTAGONISM OF TUBOCURARINE BLOCK WITH ATROPINE-NEOSTIGMINE MIXTURE IN CHILDREN

M. R. SALEM, M.D., T. TOYAMA, M.D., A. Y. WONG, M.D., H. K. JACOBS, PH.D. and E. J. BENNETT, M.D.

Department of Anesthesiology, Cook County Hospital and The Hektoen Institute for Medical Research of Cook County Hospital Chicago, Illinois, U.S.A.
Abraham Lincoln School of Medicine, University of Illinois Hospitals Chicago, Illinois, U.S.A.

Following antagonsim of tubocurarine block with a mixture of atropine 20 µg/kg and neostigmine 50 µg/kg in 20 children, heart rate decreased from a control value of 110.4 beat/min to 90.1 at 5 min and 89.2 at 6 min (P<0.02). Stroke volume index did not change during the first 5 min from a control value of 36.3 ml. beat–1. m–2 but a significant increase to 48 ml. beat–1.m–2 was observed at the 6th and 7th mins following the injection of the mixture (P<0.05). Cardiac index and mean arterial pressure remained unaltered throughout the period of observation. Normal sinus rhythm was maintained in all patients. It was concluded that antagonism of tubocurarine with an atropineneostigmine mixture does not produce any important haemodynamic change in children.


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