British Journal of Anaesthesia, 1977, Vol. 49, No. 9 881-885
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia
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ENFLURANE (ËTHRANE) ANAESTHESIA IN MAN
Metabolism and effects on biochemical and haematological variables
King's College Hospital and Medical School, Department of Anaesthetics Denmark Hill, London SE5 9RS
In 10 patients serum inorganic fluoride increased to a mean peak value of 16µmol. litre1 after 2 h of enflurane anaesthesia. Four days after anaesthesia, serum inorganic fluoride had decreased to the values before operation. The maximum daily inorganic fluoride excretion in urine (UFV) did not exceed 200 µmol. litre1. In a group of 20 patients routine biochemical and haematological variables were measured before and after enflurane anaesthesia. There were only minor changes in these variables, attributable to the surgical procedure. It is concluded that renal dysfunction is unlikely to follow enflurane anaesthesia in patients with previously normal hepatic and renal function.
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