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British Journal of Anaesthesia, 1977, Vol. 49, No. 9 881-885
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia


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ENFLURANE (ËTHRANE) ANAESTHESIA IN MAN

Metabolism and effects on biochemical and haematological variables

I. M. CORALL, L.R.C.P., M.R.C.S., F.F.A.R.C.S., K. M. KNIGHTS, A.I.M.L.S. and L. STRUNIN, M.D., F.F.A.R.C.S.

King's College Hospital and Medical School, Department of Anaesthetics Denmark Hill, London SE5 9RS

In 10 patients serum inorganic fluoride increased to a mean peak value of 16µmol. litre–1 after 2 h of enflurane anaesthesia. Four days after anaesthesia, serum inorganic fluoride had decreased to the values before operation. The maximum daily inorganic fluoride excretion in urine (UFV) did not exceed 200 µmol. litre–1. In a group of 20 patients routine biochemical and haematological variables were measured before and after enflurane anaesthesia. There were only minor changes in these variables, attributable to the surgical procedure. It is concluded that renal dysfunction is unlikely to follow enflurane anaesthesia in patients with previously normal hepatic and renal function.


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J. H. LEWIS, H. J. ZIMMERMAN, K. G. ISHAK, and F. G. MULLICK
Enflurane Hepatotoxicity: A Clinicopathologic Study of 24 Cases
Ann Intern Med, June 1, 1983; 98(6): 984 - 992.
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