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British Journal of Anaesthesia, 1977, Vol. 49, No. 9 865-870
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECT OF THIOPENTONE ON MYOCARDIAL FUNCTION

J. H. CHAMBERLAIN, M.B., B.S., M.R.C.P., D.I.C., R. G. F. L. SEED, M.B., B.S., F.F.A.R.C.S. and D. C. W. CHUNG, M.D., F.F.A.R.C.S.

Department of Clinical Physiology, Guy's Hospital London SE1 9RT
Department of Anaesthetics, Guy's Hospital London SE1 9RT

Correspondence to J. H. C.

In a canine preparation designed to separate myocardial from peripheral cardiovascular effects of the drug, it was found that thiopentone produced minimal depression of the heart. Only in much greater concentrations was significant depression found. It is concluded that the cardiovascular effects of thiopentone i.v. are not a direct effect on the heart.


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