Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HALL, G. M.
Right arrow Articles by LISTER, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HALL, G. M.
Right arrow Articles by LISTER, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1977, Vol. 49, No. 9 855-863
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia

other

PORCINE MALIGNANT HYPERTHERMIA. V: FATAL HYPERTHERMIA IN THE PIETRAIN PIG, ASSOCIATED WITH THE INFUSION OF {alpha}-ADRENERGIC AGONISTS

G. M. HALL, M.B., B.S., PH.D., F.F.A.R.C.S., J. N. LUCKE, B.V.SC., M.R.C.V.S., PH.D., D.V.A. and D. LISTER, B.SC., PH.D.

Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital DuCane Road, London W12 0HS
Department of Veterinary Surgery, University of Bristol Langford House, Langford, Bristol
ARC Meat Research Institute Langford, Bristol

Correspondence to G. M. H.

The effects of the administration of noradrenaline alone, and noradrenaline with either phentolamine or propranolol, on thermogenesis and substrate mobilization were investigated in six Pietrain (MH-susceptible) and six Large White (unsusceptible) pigs. The infusion of noradrenaline alone produced a significantly increased lipolytic response and a significantly decreased hyperglycaemic response in Pietrain pigs compared with the Large White breed. Although noradrenaline alone produced only a small increase in body temperature in both breeds, the administration of noradrenaline with propranolol in two Pictrain pigs was associated with the development of fatal hyperthermia. In a further experiment, phenylephrine or isoprenaline was infused into six Pietrain pigs. Three pigs, receiving phenylephrine, became hyperthermic and died, whereas isoprenaline had no effect on body temperature. The results demonstrate the importance of {alpha}-adrenergic stimulation to heat production in MH-susceptible pigs.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.