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British Journal of Anaesthesia, 1977, Vol. 49, No. 9 847-853
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia

other

MACROAUTORADIOGRAPHIC STUDY OF THE DISTRIBUTION AND EXCRETION OF 14C-PENTOBARBITONE IN RATS PRETREATED WITH PHENOBARBITONE

T. SHIN, M.D., S. NAKAMURA, M.D. and A. SHIGEMATSU, M.D., PH.D.

Department of Anaesthesiology, Faculty of Medicine, Kyushu University 812 Fukuoka City, Japan

The distribution and excretion of pentobarbitone were studied, using macroautoradiography, in two groups of rats at times ranging from 1 min to 70 min after the i.v. injection of 100 µCi given as 30 mg/kg of 14C-pentobarbitone. In a control group, the carbon-14 concentration (concentration of pentobarbitone in the brain remained always greater than that in heart blood (unchanged pentobarbitone and metabolites). In a group subjected to enzyme induction (pretreated with phenobarbitone), however, the carbon-14 concentration in the brain exceeded that in the heart blood initially and then decreased rapidly. In the induced group, the carbon-14 concentration in the urine and small intestine (almost all of which was metabolites) increased with time. In particular, 70 min after the injection, the carbon-14 concentration in the small intestine of the induction group was twice that of the control group. It was concluded that in the induction group the rapid decrease in carbon-14 concentration in the brain was mainly a result of an increase in the metabolic breakdown of pentobarbitone in the liver.


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