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British Journal of Anaesthesia, 1977, Vol. 49, No. 12 1251-1258
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

THE INHIBITION OF SERUM CHOLINESTERASE BY UREA: Mechanism of action and application in the typing of abnormal genes

H. K HANEL, M.SC. and J. VIBY-MOGENSEN, M.D.

Department of Clinical Chemistry, Bispebjerg Hospital; Department of Anaesthesia, Rigshospitalet; Department of Anaesthesia,Herlev Hospital; University Hospitals of Copenhagen University Copenhagen, Denmark

Address for correspondence: H. K. Hanel, Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen,Denmark.

The mechanism of action of urea on serum cholinesterase and the application of the inhibition by urea in the typing of the abnormal genes of this enzyme were investigated. Urea caused a competitive, irreversible inhibition of serum cholinesterase, which was most pronounced for the abnormal enzymes. Urea inhibition, used with dibucaine inhibition, allowed differentiation between all known genotypes of locus E1. In the differentiation or rarer genotypes, the combination of urea numbers (percentage inhibition of serum cholinesterase activity caused by urea 5 mol litre-1) and dibucaine numbers was found, in certain situtions, to be superior to the classical combination of fluoride and dibucaine numbers.


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