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British Journal of Anaesthesia, 1977, Vol. 49, No. 12 1189-1198
© 1977 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

HAEMODYNAMIC RESPONSES TO ENFLURANE ANAESTHESIA AND HYPOVOLAEMIA IN THE DOG, AND THEIR MODIFICATION BY PROPRANOLOL

B. F. HORAN, M.B., B.s., F.F.A.R.c.*, C. PAYS-ROBERTS, M.A., D.M., PH.D., F.F.A.R.c.s.{dagger},, W. K. HAMILTON, M.D.{ddagger} and J. G. ROBERTS, M.B., B.s., D.PHIL., F.F.A.R.A.c.§

NufIield Department of Anaesthetics, University of Oxford,The Radcliffe Infirmary Oxford

Requests for reprints to C. P.-R.

The haemodynamic responses to minumum equipotent concentrations of halothane and enflurance were compared in seven dogs. The haemodynamic responses to increasing concentrations of enflurane, and to induced hypovolaemia during enflurane anaesthesia, were studied in the same dogs, both before and after administration of propranolol 0.3 mg kg-1 i.v. In equipotent concentrations, enflurane caused marginally greater impairment of left ventricular function than halothane, and caused a dose-dependent reduction of arterial pressure, cardiac output and myocardial contractility. Following administration of propranolol, these haemodynamic effects of enflurane were marked, and withdrawal of 20% of estimated blood volume was tolerated poorly.

*Present addresses :Department of Anaesthetics, St Vincent's Hospital,Darlinghurst, N.S.W. 2010, Australia.

{dagger}Present addresses :Department of Anaesthesia, University of Bristol,Royal Infirmary, Bristol BS2 8HW.

{ddagger}Present addresses :Department of Anesthesiology, University of California,San Francisco Medical Center, San Francisco, U.S.A.

§§Present addresses :Department of Anaesthesia, Flinders University of South Australia, Bedford Park, South Australia 5042.


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