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British Journal of Anaesthesia, 1976, Vol. 48, No. 4 347-354
© 1976 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

INTRADERMAL STUDY OF A NEW LOCAL ANAESTHETIC AGENT: APTOCAINE

F. REYNOLDS, M.D., F.F.A.R.C.S., T. H. L. BRYSON, F.F.A.R.C.S. and A. D. G. NICHOLAS, F.F.A.R.C.S.

Department of Pharmacology, St Thomas's Hospital Medical School London S.E.I.
The Liverpool Maternity Hospital Liverpool
The Jessop Hospital for Women Sheffield

In a double-blind trial in 28 human volunteers, a new local anaesthetic agent, aptocaine, was compared intradermally at 1, 2 and 3% concentrations with lignocaine 2% and bupivacaine 0.5%. In a second trial in 27 subjects, 1% aptocaine was compared with mepivacaine and prilocaine, both 1, 2 and 3 %. In terms of activity as determined by area of anaesthesia, and of duration of action, aptocaine was similar to mepivacaine and more active and long-lasting than lignocaine and prilocaine. By this route aptocaine also appeared longer-lasting than bupivacaine. Duration of action was unaffected by concentration. Aptocaine had marked vasoconstrictor activity, which was maximal at 1%. These local anaesthetic properties suggest that aptocaine merits clinical trials, especially in dentistry.


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