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British Journal of Anaesthesia, 1976, Vol. 48, No. 4 341-346
© 1976 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PHARMACOKINETICS OF PANCURONIUM IN PATIENTS WITH NORMAL AND IMPAIRED RENAL FUNCTION

K. MCLEOD, M.B., CH.B., F.F.A.R.C.S., M. J. WATSON, B.SC., PH.D. and M. D. RAWLINS, B.SC., M.D., M.RX.P.

Department of Anaesthesia
Department of Clinical Biochemistry
Department of Pharmacological Sciences; University of Newcastle Tyne, Newcastle upon Tyne NE1 7RU.

Correspondence to Dr K. McLeod

Plasma concentrations of pancuronium were measured using a fluorimetric method in six patients with normal renal function and seven patients in chronic renal failure. A two-compartment open model was used in the pharmacokinetic analysis of the data. With this model, the clearance of pancuronium was found to be reduced significantly in the patients with renal failure, and in these individuals the volume of the central (distribution) compartment was increased significantly. The clinical implications of these findings are discussed.


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