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British Journal of Anaesthesia, 1976, Vol. 48, No. 4 309-314
© 1976 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DIAZEPAM IN THE PROPHYLAXIS OF LIGNOCAINE SEIZURES

B. AUSIKSCH, M.D., M. H. MALAGODI, PH.D. and E. S. MUNSON, M.D.

Departments of Anesthesiology and Pharmacology and Therapeutics, University of Florida College of Medicine, Box 721, J. Hillis Miller Health Center, Gainesville, Florida 32610, U.S.A. Reprint requests to B. A.

Diazepam 0.05–0.25 mg/kg increased the dose of lignocaine required to cause seizures in Rhesus monkeys by 24–34%. Spontaneous ventilation was maintained adequately during lignocaine administration following diazepam treatment and no adverse cardiovascular effects occurred. Before the onset of lignocaine-induced seizures in non-treated animakj the unimals appeared to be drowsy. However, prior administration of diazepam masked this effect. Convulsions were controlled by smaller doses of diazepam in non-treated animals than in diazepam-treated animak Also, the animals that were pretreated with diazepam had a greater duration of depression after seizure.


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