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British Journal of Anaesthesia, 1976, Vol. 48, No. 4 297-304
© 1976 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PORCINE MALIGNANT HYPERTHERMIA. I: METABOLIC AND PHYSIOLOGICAL CHANGES

J. N. LUCRE, B.V.SC., M.R.C.V.S., D.V.A., G. M. HALL, M.B., B.S., F.F.A.R.C.S. and D. LISTER, B.SC, PH.D.

Department of Veterinary Surgery, University of Bristol, Langford House Bristol
Department of Anaesthesia, Royal Postgraduate Medical School, Hammersmith Hospital London W12 OHS.
Meat Research Institute Langford, Bristol.

Correspondence to G. M. Hall, Department of Anaesthesia, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 OHS.

Porcine malignant hypothermia was studied in seven Retrain pigs under standardized experimental conditions. In five animals malignant hyperthermia was triggered with suxamethonium and halothane, but in two pigs suxamethonium alone was used. Characteristic metabolic and physiological changes were found and these are discussed with regard to a possible mechanism to explain the malignant nature of the syndrome.


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