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British Journal of Anaesthesia, 1974, Vol. 46, No. 4 282-287
© 1974 The Board of Management and Trustees of the British Journal of Anaesthesia

other

PANCURONIUM IN MATERNAL AND FOETAL SURUM

G. A. H. HEANEY

Attempts to quantify minute amounts of pancuronium bromide in serum have been complicated by the presence of other anaesthetic drugs. A method of bioassay for determining absolute amounts of this relaxant in maternal in materal venous and cord blood is described. Data in a selected series of patients having pancuronium bromide for Caesarean section under general anaesthesia are presented, using three doses in the clinical range. Maternal venous levels of 0.2–2 µg/ml pancuronium were found. Assayable pancuronium was present in the cord samples of only 2 out of 19 patients. It is suggested that in those infant sera containing pancuroinum there was a maternal factor operating which predisposed to placental passage of the relaxant.


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