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British Journal of Anaesthesia, 1974, Vol. 46, No. 4 263-267
© 1974 The Board of Management and Trustees of the British Journal of Anaesthesia

other

ACID-BASE CHANGES IN ARTERIAL BLOOD AND CEREBROSPINAL FLUID DURING CRANIOTOMY AND HYPERVENTILATION

T. V. CAMPKIN, R. G. BARKER, M. PABARI and L. H. GROVE

Several studies in healthy man and animals have shown biochemical evidence of a change in cerebral glucose utilization to anaerobic metabolism during hyperventilation and hypocarbia. The increase in lactate in the cerebrospinal fluid was moderate at a Paco2 of 20 mm Hg but became more marked at lower values of Paco2. In this investigation patients were studied, during craniotomy, both at normal body temperature and under hypothermia. Arterial blood was sampled at hourly intervals and one sample of ventricular c.s.f. was obtained during the period of hyperventilation. With the exception of one patient in the hypothermia group no evidence of an excessive increase in c.s.f. lactate (indicative of deficient cerebral oxygenation) was seen at Paco2 values of approximately 20 mm Hg.


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