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British Journal of Anaesthesia, 1973, Vol. 45, No. 7 691-696
© 1973 The Board of Management and Trustees of the British Journal of Anaesthesia

other

THE EFFECT OF PROPANIDID ON MYOCARDIAL BLOOD FLOW AND OXYGEN CONSUMPTION IN THE DOG

G. SMITH, B.SC., M.D., F.F.A.R.C.S., J. P. VANCE, M.B., CH.B., F.F.A.R.C.S. and D. M. BROWN, M.B., CH.B., F.F.A.R.C.S.

University Department of Anaesthesia, Western Infirmary Glasgow
Department of Anaesthetics, Royal Infirmary Glasgow

Using the xenon-133 clearance technique for measurement of myocardial blood flow, it was shown that propanidid produced a large but transient increase in myocardial oxygen availability in the dog. With 5 mg/kg and 10 mg/kg, myocardial blood flow rose by 26% and 75% respectively, independent of any change in perfusion pressure, cardiac output or myocardial oxygen consumption. Cremophor-EL was found to have no effect on myocardial blood flow.


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