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British Journal of Anaesthesia, 1973, Vol. 45, No. 4 394-398
© 1973 The Board of Management and Trustees of the British Journal of Anaesthesia

case-report

COMBINED NEPHROTOXICITY OF GENTAMICIN AND METHOXYFLURANE ANAESTHESIA IN MAN

A Case Report

R. I. MAZZE, M.D. and M. J. COUSINS, M.B.B.S., F.F.A.R.C.S., F.F.A.R.A.C.S.

Department of Anesthesia, Stanford University School of Medicine Stanford, California 94305
Vererans Administration Hospital Palo Alto, California 94304, U.S.A.

The clinical and biochemical findings are decribed in a patient who developed nephrotoxicity due to the combined effects of methoxyflurane anaesthesia and gentamicin. Following methoxyflurane anaesthesia mild nephrotoxicity occurred which rapidly increased in severity when gentamicin therapy was commenced, suggesting that the nephrotoxicity of these two drugs may be additive.


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M. J. Cousins and R. I. Mazze
Methoxyflurane Nephrotoxicity: A Study of Dose Response in Man
JAMA, September 24, 1973; 225(13): 1611 - 1616.
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