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British Journal of Anaesthesia, 1973, Vol. 45, No. 4 376-380
© 1973 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECT OF EPIDURAL BLOCKADE ON THE PENTAZOCINE-INDUCED INCREASE IN PLASMA CATECHOLAMINES AND BLOOD PRESSURE

S. TAKKI, M.D., P. NIKKI, M.D., T. TAMMISTO, M.D. and A. JÄÄTTELÄ, M.D.

Meilahti Hospital Haartmaninkatu 4, Helsinki 29, Finland

To elucidate the mechanism and site of action of pentazocine-induced sympathetic stimulation, plasma catecholamines were measured after intravenous pentazocine 1.2 mg/kg in 20 patients with epidural blockade extending to different levels. In patients with low epidural blockade (below T8) total plasma catecholamines increased during the 20-minute observation period to a maximum of about 40% 5 minutes after the injection of pentazocine. The increase in catecholamines comprised mainly noradrenaline and corresponded to the rise in blood pressure and heart rate. In patients with high epidural blockade (over T6) pentazocine caused a slight fall in catecholamine level. In these patients the pentazocine-induced rise in blood pressure was nearly abolished. It is considered that the site of pentazocine-induced sympathetic stimulation is central.


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