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British Journal of Anaesthesia, 1973, Vol. 45, No. 4 358-362
© 1973 The Board of Management and Trustees of the British Journal of Anaesthesia

other

NEPHROTOXICITY FROM METHOXYFLURANE ANAESTHESIA: A 6-YEAR RETROSPECTIVE STUDY*

R. B. URGENA, M.D. and S. D. GERGIS, M.D.

College of Medicine, University of Iowa Iowa City, Iowa 52240 U.S.A.

Methoxyflurane was administered to 1196 patients during a 6-year period and the records of 1000 patients were reviewed. Two patients developed severe renal insufficiency but survived. There were 17 other patients who showed an inappropriate postoperative diuresis but they did not develop severe renal insufficiency. The records of 1000 patients given general anaesthesia other than methoxyflurane were also studied. None exhibited inappropriate diuresis. The mortality rate from all causes was comparable in the two groups.

* Supported in part by General Research Support Grant FR05372 from the General Research Support Branch, Division of Research Facilities and Resources, National Institutes of Health.


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