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British Journal of Anaesthesia, 1973, Vol. 45, No. 4 306-312
© 1973 The Board of Management and Trustees of the British Journal of Anaesthesia

other

AN ANIMAL MODEL FOR COMBINED METHOXYFLURANE AND GENTAMICIN NEPHROTOXICITY

G. A. BARR, M.D.*, R. I. MAZZE, M.D.*, M. J. COUSINS, M.B., B.S., F.F.A.R.A.C.S, F.F.A.R.C.S.* and JON C. KOSEK, M.D.**

*Departments of Anesthesia Stanford University School of Medicine Stanford, California 94305.
**Department of Pathology Stanford University School of Medicine Stanford, California 94305
Veterans Administration Hospital Palo Alto, California 94304, U.S.A.

Fischer 344 rats receiving gentamicin 20 mg/kg/day prior to and following 0.5% methoxyflurane anaesthesia for 31/2 hours had greater renal insufficiency than rats treated with either drug alone. Polyuria, progressively increasing BUN and decreasing urea nitrogen clearance were noted; a renal histological lesion with features of both drug treatments was seen with electron microscopy. Similar, atypically severe nephrotoxicity has been observed in patients treated with methoxyflurane and gentamicin, suggesting that toxic drug interaction also occurs in humans following combined administration of these drugs.


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