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British Journal of Anaesthesia, 1972, Vol. 44, No. 4 391-400
© 1972 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ABSENCE OF ACCUMULATION OF METHOXYFLURANE DURING INTERMITTENT SELF-ADMINISTRATION FOR PAIN RELIEF IN LABOUR

I. P. LATTO, M. ROSEN and M. J. MOLLOY

Department of Anaesthetics, University Hospital of Wales Cardiff, CF4 4XN, Wales.

The blood concentration of methoxyflurane and the ventilation during intermittent self-administered inhalation analgesia were measured in 16 mothers (12 multigravidae) during labour. The blood methoxyflurane concentrations did not show accumulation over a mean period of inhalation of 77.6 min. Yet from theoretical deductions some accumulation would be anticipated. In a longer case it was shown that the mother, in spite of constant overall ventilation, breathed less methoxyflurane per contraction as labour progressed, so maintaining a reasonably steady blood level. This indicates that the conscious mother, unlike the anaesthetized subject, controls the uptake of methoxyflurane.


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