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British Journal of Anaesthesia, 1972, Vol. 44, No. 4 374-380
© 1972 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

SENSITIVITY TO DIMETHYLTUBOCURARINE AND TOXIFERINE WITH SPECIAL REFERENCE TO SERUM PROTEINS

J. STOVNER*, L. THEODORSEN and E. BJELKE

Department of Anaesthesia, Clinical Laboratory, The Cancer Registry of Norway; The Norwegian Radium Hospital Oslo, Norway

In a consecutive series of 100 female patients undergoing abdominal surgery muscular relaxation was obtained in half with dimethyltubocurarine and in half with toxiferine. The required dose of these relaxants (mg/m2 body surface) showed a lower individual variation than the requirements of any other non-depolarizing relaxants investigated under similar conditions. Neostigmine 0.5 mg reversed the block by dimethyltubocurarine better than the block by toxiferine. The requirement of dimethyltubocurarine showed no detectable correlation with any serum protein fraction. The requirement of toxiferine displayed a negative correlation with serum albumin (r{equiv}—0.46) and only weak positive correlation with the globulins. From the present and previous studies it is concluded that charge-dissipating ethyl and allyl quaternization leads to positive correlation with albumin. Methylquaternized compounds, on the other hand, do not show this effect and may even display a negative albumin correlation as seen with toxiferine. Free phenolic hydroxyl groups induce positive correlations with the globulins while free alcoholic hydroxyl groups do not.

* Present address: Rikshospitalet, Oslo


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