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British Journal of Anaesthesia, 1972, Vol. 44, No. 4 370-374
© 1972 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

THE PLACENTAL TRANSFER OF PANCURONIUM BROMIDE

ISOBEL SPEIRS and A. W. SlM

University Department of Anaesthetics, Glasgow Royal Infirmary and Royal Maternity Hospital, Glasgow, Scotland
Organon Laboratories Ltd, Newhouse, Lanarkshire, Scotland.

A study has been undertaken to determine the extent to which pancuronium bromide crosses the placental membrane. After rapid intravenous injection of the drug in a mean dose of 0.08 mg/kg to the mother, the drug was detected in neonatal urine in 11 of 20 patients in varying concentrations. None of the infants showed clinical evidence of myoneural blockade.


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Ann Intern Med, January 1, 1978; 88(1): 64 - 68.
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