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British Journal of Anaesthesia, 1972, Vol. 44, No. 4 330-334
© 1972 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

THE EFFECTS OF THALAMONAL ON CEREBRAL CIRCULATION AND OXYGEN CONSUMPTION IN MAN

A. SARI, Y. OKUDA and H. TAKESHITA

Department of Anesthesiology, Yamaguchi University School of Medicine 1144 Kogushi, Nishi-ku Ube, Yamaguchi, Japan.

The effects of Thalamonal on cerebral circulation and oxygen consumption were studied in ten normal healthy patients before operations. After the administration of Thalamonal 0.1 ml/kg, cerebral blood flow (c.b.f.) and Paco2 increased from a control value of 48 +4.2 to 51 + 3.9 ml/100 g/min and from 34.6 ±1.2 to 37.1 + 1.8 mm Hg, respectively, but these were not statistically significant changes. Oxygen consumption (CMRo2) increased from a control value of 3.06 + 0.22 to 3.08 ±0.30 ml/100 g/min during neuroleptanalgesia with Thalamonal, but this change was also not significant. It was concluded that Thalamonal had no significant effect on c.b.f. and CMRo2 of man when Paco2 was within normal limits and body temperature remained unchanged.


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