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British Journal of Anaesthesia, 1971, Vol. 43, No. 12 1129-1135
© 1971 The Board of Management and Trustees of the British Journal of Anaesthesia

other

THE RESPIRATORY EFFECTS OF A POTENT ANALGESIC (GPA 2087)* IN MAN

P. W. R. SMETHURST, M.B., CH.B., F.F.A.R.C.S.*, W. H. FORREST, JR., M.D. and J. HAYDEN, R.N.

The Department of Anesthesia, Stanford University School of Medicine Stanford, California
Veterans Administration Hospital Palo Alto, California, U.S.A.

The respiratory depressant effects of a potent analgesic (GPA 2087) were compared with morphine in a randomized double-blind cross-over study in human volunteers. Using a rebreathing technique, carbon dioxide response curves were plotted automatically with a special-purpose analog computer. The respiratory depressant relative potency of GPA 2087 to morphine was found to be 1.21 with lower and upper 95 per cent confidence limits of 0.88 and 2.04. Our best estimate based on the displacement of the respiratory response curve is that GPA 2087 8 mg is the equivalent of morphine 10 mg in our population of volunteers.

*Geigy Pharmaceuticals, Ardsley, New York, U.S.A.

*Present address: Salisbury General Infirmary, Odstock Branch, Salisbury, Wiltshire, England.


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