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British Journal of Anaesthesia, 1971, Vol. 43, No. 12 1121-1125
© 1971 The Board of Management and Trustees of the British Journal of Anaesthesia

other

THE RELATIVE INFLUENCE OF WEIGHT AND OF "NERVOUS TYPE" ON THE TOLERANCE OF AMYLOBARBITONE SODIUM

G. S. CLARIDGE, PH.D.

University of Glasgow, Department of Psychological Medicine, Southern General Hospital Glasgow, S.W.I, Scotland

A large quantity of available data was re-analyzed in order to examine the relative contribution of body weight and nervous typology on the tolerance of intravenously administered amylobarbitone sodium, given in doses sufficient to reach the "sedation threshold". Results for 158 neurotic and 34 normal subjects revealed uniformly low, and frequently non-significant, correlations between body weight and the absolute amount of drug required to induce sedation. On the other hand, consistently significant correlations were found between drug tolerance and various behavioural and physiological indices of central nervous arousal, which previous work has shown to be related to personality differences. It was concluded that nervous type variations make a greater contribution than body weight to the tolerance of amylobarbitone sodium as assessed by the induction method.


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