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British Journal of Anaesthesia, 1966, Vol. 38, No. 5 401-405
© 1966 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CLINICAL STUDIES OF INDUCTION AGENTS XV: A COMPARISON OF THE CUMULATIVE EFFECTS OF THIOPENTONE, METHOHEXTTONE AND PROPANIDID

R. S. J. CLARKE and J. W. DUNDEE

Department of Anaesthetics, The Queen's University of Belfast Northern Ireland

Thiopentone, methohexitone and propanidid have been given by intermittent dosage as main agent for a series of body surface operations. The requirements over the first hour show a marked falling off with the barbiturates but little decline with propanidid. This supports the experimental findings that propanidid is rapidly destroyed in the body whereas the other agents are translocated into storage depots.


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