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British Journal of Anaesthesia, 1962, Vol. 34, No. 6 397-409
© 1962 The Board of Management and Trustees of the British Journal of Anaesthesia

review-article

HISTAMINE IN ANAESTHESIA

A Short Survey

PATRICK MURPHY

Department of Physiology, The London Hospital Medical College London

A brief account is given of the relevant pharmacology and physiology of histamine, followed by a review of some of the recent literature relating to the release of histamine by drugs in anaesthetic use.

The question naturally arises, to what extent need the anaesthetist take the possible release of histamine into account when assessing the likely effect of any drug on his patients. It would appear that the only circumstances in which he need take any note of histamine release are when morphine and curare are used in the asthmatic and when trimetaphan is used to induce hypotension.


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