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British Journal of Anaesthesia, 1962, Vol. 34, No. 6 379-385
© 1962 The Board of Management and Trustees of the British Journal of Anaesthesia

other

A CLINICAL STUDY OF INTRAVENOUS ANAESTHESIA WITH A EUGENOL DERIVATIVE, G.29.505

D. A. RIGHT and J. P. PAYNE

Department of Anaesthesia, Postgraduate Medical School of London and Hammersmith Hospital London

A dervative of eugenol, G.29.505, was given intravenously to induce anaesthesia in 100 adult patients for operations ranging from minor gynaecological procedures to pneumonectomies and gastrectomies.

The grug when given in a 5 per cent solution produced with a transient respiratory stimulation followed by a brief of apnoen. No significant effect were observed on the rate aand rhythm of the heart, on blood pressure, or on cardiac output. There was, however, an increase in skin blood flow as measured by digital plethysmography.

Thirty-three patients developed venous thrombosis around the site of injection and this incidence is too high to justify its use except in special circumstances.


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