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British Journal of Anaesthesia, 1962, Vol. 34, No. 6 357-362
© 1962 The Board of Management and Trustees of the British Journal of Anaesthesia

other

THE INFLUENCE OF CERTAIN GANGLIONIC BLOCKING AGENTS ON NEUROMUSCULAR TRANSMISSION

A. R. DE C. DEACOCK and R. L. HARGROVE

Department of Anaesthetics, King's College Hospital London

Experiments to investigate the action of hexa-methonium, trimetaphan and phenactropinium on neuromuscular transmission in intact, anaesthetized dogs are described. Blood pressure was maintained throughout by infusion of noradrena-line so that the effects of hypotension should not obscure the results.

All three drugs under investigation produced complete neuromuscular block. The absence of initial muscle fasciculation and the response to neostigmine indicated that the block was of non-depolarizing type. Trimetaphan and phenactro-pinium were found to depress plasma cholines-terase activity.

Quantitative evaluation of the results suggests that clinically significant depression of neuro-muscular transmission may be produced by trimetaphan and phenactropinium, but not by hexamethonium.


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