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BJA Advance Access originally published online on May 21, 2009
British Journal of Anaesthesia 2009 103(1):82-88; doi:10.1093/bja/aep135
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© The Author [2009]. Published by Oxford University Press on behalf of The Board of Directors of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournal.org

Pharmacological optimization of tissue perfusion

N. Mongardon, A. Dyson and M. Singer*

Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research and Department of Medicine, University College London, London WC1E 6BT, UK

* Corresponding author. E-mail: m.singer{at}ucl.ac.uk

After fluid resuscitation, vasoactive drug treatment represents the major cornerstone for correcting any major impairment of the circulation. However, debate still rages as to the choice of agent, dose, timing, targets, and monitoring modalities that should optimally be used to benefit the patient yet, at the same time, minimize harm. This review highlights these areas and some new pharmacological agents that broaden our therapeutic options.

Keywords: arterial pressure, drug effects; cardiovascular system, effects; heart, cardiac output; oxygen, therapy; pharmacology, agonists adrenergic


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