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BJA Advance Access originally published online on August 20, 2008
British Journal of Anaesthesia 2008 101(5):700-704; doi:10.1093/bja/aen244
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy

A. Agarwal1,*, S. Gautam1, D. Gupta1, S. Agarwal1, P. K. Singh1 and U. Singh2

1 Department of Anaesthesiology
2 Department of Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Type V B/11, Lucknow 226 014, India

* Corresponding author. E-mail: aagarwal{at}sgpgi.ac.in

Background: Postoperative pain is the dominating complaint and the primary reason for prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the efficacy of a single preoperative dose of pregabalin for attenuating postoperative pain and fentanyl consumption after laparoscopic cholecystectomy.

Methods: Sixty adults (16–60 yr), ASA physical status I and II, of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, double-blind study. Subjects were divided into two groups of 30 each to receive either a matching placebo or pregabalin 150 mg, administered orally 1 h before surgery. Postoperative pain (static and dynamic) was assessed by a 100 mm visual analogue scale, where 0, no pain; 100, worst imaginable pain. Subjects received patient-controlled i.v. fentanyl analgesia during the postoperative period. Results were analysed by Student's t-test, {chi}2 test, Mann–Whitney U-test, and Fisher's exact test.

Results: Postoperative pain (static and dynamic) and postoperative patient-controlled fentanyl consumption were reduced in the pregabalin group compared with the placebo group (P<0.05). Side-effects were similar in both groups.

Conclusions: A single preoperative oral dose of pregabalin 150 mg is an effective method for reducing postoperative pain and fentanyl consumption in patients undergoing laparoscopic cholecystectomy.

Keywords: analgesia, postoperative; analgesia, pre-emptive; analgesics non-opioid; pain, postoperative


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Pregabalin for Acute Pain Management: A Shift in Paradigm
Aisha Siddqui, et al.
British Journal of Anaesthesia, 14 Oct 2008 [Full text]
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Sujeet Gautam, et al.
British Journal of Anaesthesia, 24 Oct 2008 [Full text]

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