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British Journal of Anaesthesia 2008 100(3):288-298; doi:10.1093/bja/aem406
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 BJA: March 2008
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Statins and sepsis

F. Gao1,*,{dagger}, L. Linhartova1, A. McD. Johnston2 and D. R. Thickett3,{dagger}

1 Academic Department of Anaesthesia, Critical Care, and Pain, Heart of England NHS Foundation Trust, University of Warwick, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
2 Division of Medical Sciences University of Birmingham, Birmingham, UK
3 Lung Injury and Fibrosis Treatment Programme, University of Birmingham, Birmingham, UK

* Corresponding author. E-mail: f.g.smith{at}bham.ac.uk

Severe sepsis and septic shock is common and frequently fatal. Over the last few years, the primary treatments demonstrated to improve outcome from several major clinical trials have finally emerged. However, translating these recent therapeutic advances to routine clinical practice has proven controversial, and new approaches of additional strategies are continued to be developed. Given their pleiotropic effects related to many pathophysiological determinants of sepsis, statin therapy could be the next step in the search for adjuvant therapy. A future challenge may be to test both the efficacy and the safety by large randomized controlled clinical trials ascertaining the effects of statins administered at the onset of sepsis and in patients with severe sepsis or septic shock admitted into intensive care units.

Keywords: complications, sepsis; infection; immune response; pharmacology, statins

{dagger} Declaration of interest. Professor Gao is the Chief Investigator of RCT on ‘Statin therapy in early sepsis can modulate the development of severe sepsis compared to placebo’ (ASEPSIS trial). The trial received a pump-prime research grant from Pfizer. Professor Gao and Dr Thickett have received travelling sponsorships from pharmaceutical and industrial companies to attend national and international conferences.


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